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Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer.


ABSTRACT: A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals' genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether IL-17F genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reactive protein (CRP) concentration as the response. High CRP levels were associated with a high risk of colorectal cancer (OR (95% CI) = 3.58 (2.65?4.82) for the highest quartile vs. lowest quartile). After adjusting for potential confounding factors, high pattern scores were associated with a high risk of colorectal cancer (OR (95% CI) = 9.98 (6.81?14.62) for the highest quartile vs. lowest quartile). When stratified by the IL-17F rs763780 genotype, this association was stronger for individuals carrying the C allele (p for interaction = 0.034), particularly for individuals with rectal cancer (p for interaction = 0.011). In conclusion, a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk. Moreover, this association could be modified according to the IL-17F rs763780 genotype and anatomic site.

SUBMITTER: Cho YA 

PROVIDER: S-EPMC6024771 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Inflammatory Dietary Pattern, <i>IL-17F</i> Genetic Variant, and the Risk of Colorectal Cancer.

Cho Young Ae YA   Lee Jeonghee J   Oh Jae Hwan JH   Chang Hee Jin HJ   Sohn Dae Kyung DK   Shin Aesun A   Kim Jeongseon J  

Nutrients 20180605 6


A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals' genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether <i>IL-17F</i> genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reac  ...[more]

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