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Vitamin D Status and Immune Health Outcomes in a Cross-Sectional Study and a Randomized Trial of Healthy Young Children.


ABSTRACT: In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8?5.9 years (n = 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8?8.7 years old (n = 77) in Montreal, Canada. Vitamin D status and ex vivo immune function were assessed. In study 1 (male: n = 242; 53%), plasma IL-6, TNF? and CRP were significantly higher (p < 0.05) in children with 25-hydroxyvitamin D (25(OH)D) ? 75 nmol/L compared to.

SUBMITTER: Brett NR 

PROVIDER: S-EPMC6024793 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Vitamin D Status and Immune Health Outcomes in a Cross-Sectional Study and a Randomized Trial of Healthy Young Children.

Brett Neil R NR   Lavery Paula P   Agellon Sherry S   Vanstone Catherine A CA   Goruk Susan S   Field Catherine J CJ   Weiler Hope A HA  

Nutrients 20180527 6


In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8⁻5.9 years (<i>n</i> = 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8⁻8.7 years old (<i>n</i> = 77) in Montreal, Canada. Vitamin D status and ex vivo immune function were asses  ...[more]

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