Ontology highlight
ABSTRACT:
SUBMITTER: Cano-Ortiz L
PROVIDER: S-EPMC6024795 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cano-Ortiz Lucía L Maletich Junqueira Dennis D Comerlato Juliana J Zani André A Santos Costa Cristina C Michel Roehe Paulo P Franco Ana Cláudia AC
Viruses 20180531 6
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; A3) proteins comprise an important family of restriction factors that produce hypermutations on proviral DNA and are able to limit virus replication. Vif, an accessory protein present in almost all lentiviruses, counteracts the antiviral A3 activity. Seven haplotypes of <i>APOBEC3Z3</i> (<i>A3Z3</i>) were described in domestic cats (hap I⁻VII), and in-vitro studies have demonstrated that these proteins reduce infectivity ...[more]