Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC6025575 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Marine drugs 20180607 6
Lectins play diverse roles in physiological processes as biological recognition molecules. In this report, a gene encoding <i>Tachypleus tridentatus</i> Lectin (TTL) was inserted into an oncolytic vaccinia virus (oncoVV) vector to form oncoVV-TTL, which showed significant antitumor activity in a hepatocellular carcinoma mouse model. Furthermore, TTL enhanced oncoVV replication through suppressing antiviral factors expression such as interferon-inducible protein 16 (IFI16), mitochondrial antivira ...[more]