The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.
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ABSTRACT:
SUBMITTER: Contino G
PROVIDER: S-EPMC6025803 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.
Contino Gianmarco G Vaughan Thomas L TL Whiteman David D Fitzgerald Rebecca C RC
Gastroenterology 20170714 3
We have recently gained unprecedented insight into genetic factors that determine risk for Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multistep model of progression to EA. Newer, cost-effec ...[more]
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2012-03-15 | GSE29965 | GEO