Ontology highlight
ABSTRACT:
SUBMITTER: Klawonn AM
PROVIDER: S-EPMC6026003 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Klawonn Anna Mathia AM Fritz Michael M Nilsson Anna A Bonaventura Jordi J Shionoya Kiseko K Mirrasekhian Elahe E Karlsson Urban U Jaarola Maarit M Granseth Björn B Blomqvist Anders A Michaelides Michael M Engblom David D
The Journal of clinical investigation 20180618 7
It is critical for survival to assign positive or negative valence to salient stimuli in a correct manner. Accordingly, harmful stimuli and internal states characterized by perturbed homeostasis are accompanied by discomfort, unease, and aversion. Aversive signaling causes extensive suffering during chronic diseases, including inflammatory conditions, cancer, and depression. Here, we investigated the role of melanocortin 4 receptors (MC4Rs) in aversive processing using genetically modified mice ...[more]