Ontology highlight
ABSTRACT:
SUBMITTER: He H
PROVIDER: S-EPMC6026158 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
He Hongbin H Jiang Hua H Chen Yun Y Ye Jin J Wang Aoli A Wang Chao C Liu Qingsong Q Liang Gaolin G Deng Xianming X Jiang Wei W Zhou Rongbin R
Nature communications 20180629 1
Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown. NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-driven human diseases. Here, we show that Ori is a specific and covalent inhibitor for NLRP3 inflammasome. Ori forms a covalent bond with the cysteine 279 of NLRP3 in NACHT domain to block the interactio ...[more]