Ontology highlight
ABSTRACT:
SUBMITTER: Flores-Ibarra A
PROVIDER: S-EPMC6026190 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Flores-Ibarra Andrea A Vértesy Sabine S Medrano Francisco J FJ Gabius Hans-Joachim HJ Romero Antonio A
Scientific reports 20180629 1
Among members of the family of adhesion/growth-regulatory galectins, galectin-3 (Gal-3) bears a unique modular architecture. A N-terminal tail (NT) consisting of the N-terminal segment (NTS) and nine collagen-like repeats is linked to the canonical lectin domain. In contrast to bivalent proto- and tandem-repeat-type galectins, Gal-3 is monomeric in solution, capable to self-associate in the presence of bi- to multivalent ligands, and the NTS is involved in cellular compartmentalization. Since no ...[more]