Gating Currents in the Hv1 Proton Channel.
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ABSTRACT:
SUBMITTER: De La Rosa V
PROVIDER: S-EPMC6026397 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Gating Currents in the Hv1 Proton Channel.
De La Rosa Victor V Ramsey Ian Scott IS
Biophysical journal 20180601 12
The Hv1 proton channel shares striking structural homology with fourth transmembrane helical segment-type voltage-sensor (VS) domains but manifests distinctive functional properties, including a proton-selective "aqueous" conductance and allosteric control of voltage-dependent gating by changes in the transmembrane pH gradient. The mechanisms responsible for Hv1's functional properties remain poorly understood, in part because methods for measuring gating currents that directly report VS activat ...[more]
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