Development of a tool predicting severity of allergic reaction during peanut challenge.

ABSTRACT:

Background

Reliable prognostic markers for predicting severity of allergic reactions during oral food challenges (OFCs) have not been established.

Objective

To develop a predictive algorithm of a food challenge severity score (CSS) to identify those at higher risk for severe reactions to a standardized peanut OFC.

Methods

Medical history and allergy test results were obtained for 120 peanut allergic participants who underwent double-blind, placebo-controlled food challenges. Reactions were assigned a CSS between 1 and 6 based on cumulative tolerated dose and a severity clinical indicator. Demographic characteristics, clinical features, peanut component IgE values, and a basophil activation marker were considered in a multistep analysis to derive a flexible decision ru

SUBMITTER: Chinthrajah RS 

PROVIDER: S-EPMC6026554 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature