Ontology highlight
ABSTRACT:
SUBMITTER: Conroy S
PROVIDER: S-EPMC6026847 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20180328 7
The human P2Y<sub>2</sub> receptor ( hP2Y<sub>2</sub>R) is a G-protein-coupled receptor that shows promise as a therapeutic target for many important conditions, including for antimetastatic cancer and more recently for idiopathic pulmonary fibrosis. As such, there is a need for new hP2Y<sub>2</sub>R antagonists and molecular probes to study this receptor. Herein, we report the development of a new series of non-nucleotide hP2Y<sub>2</sub>R antagonists, based on the known, non-nucleotide hP2Y<su ...[more]