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Unanswered Questions Regarding Sex and BMP/TGF-? Signaling.

ABSTRACT: Crosstalk between the BMP and TGF-β signaling pathways regulates many complex developmental processes from the earliest stages of embryogenesis throughout adult life. In many situations, the two signaling pathways act reciprocally. For example, TGF-β signaling is generally pro-fibrotic, whereas BMP signaling is anti-fibrotic and pro-calcific. Sex-specific differences occur in many diseases including cardiovascular pathologies. Differing ratios of fibrosis and calcification in stenotic valves suggests that BMP/TGF-β signaling may vary in men and women. In this review, we focus on the current understanding of the interplay between sex and BMP/TGF-β signaling and pose several unanswered questions.

SUBMITTER: Shah TA

PROVIDER: S-EPMC6027345 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Unanswered Questions Regarding Sex and BMP/TGF-β Signaling.

Shah Tapan A TA Rogers Melissa B MB

Journal of developmental biology 20180616 2

Crosstalk between the BMP and TGF-β signaling pathways regulates many complex developmental processes from the earliest stages of embryogenesis throughout adult life. In many situations, the two signaling pathways act reciprocally. For example, TGF-β signaling is generally pro-fibrotic, whereas BMP signaling is anti-fibrotic and pro-calcific. Sex-specific differences occur in many diseases including cardiovascular pathologies. Differing ratios of fibrosis and calcification in stenotic ...[more]

PMID: 29914150

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Unanswered Questions Regarding Sex and BMP/TGF-? Signaling.

Publications

Unanswered Questions Regarding Sex and BMP/TGF-β Signaling.

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