Ontology highlight
ABSTRACT:
SUBMITTER: Watson BA
PROVIDER: S-EPMC6027391 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Watson Billy A BA Feenstra Jennifer M JM Van Arsdale Jonathan M JM Rai-Bhatti Karndeep S KS Kim Diana J H DJH Coggins Ashley S AS Mattison Gennaya L GL Yoo Stephen S Steinman Eric D ED Pira Charmaine U CU Gongol Brendan R BR Oberg Kerby C KC
Journal of developmental biology 20180615 2
During limb development, fibroblast growth factors (Fgfs) govern proximal⁻distal outgrowth and patterning. FGFs also synchronize developmental patterning between the proximal⁻distal and anterior⁻posterior axes by maintaining Sonic hedgehog (Shh) expression in cells of the zone of polarizing activity (ZPA) in the distal posterior mesoderm. Shh, in turn, maintains Fgfs in the apical ectodermal ridge (AER) that caps the distal tip of the limb bud. Crosstalk between Fgf and Shh signaling is critical ...[more]