Dataset Information

Ileum terminal antibiotic infusion affects jejunal and colonic specific microbial population and immune status in growing pigs.

ABSTRACT:

Background

Compared with oral antibiotics (primarily disrupt foregut microbiota), the present study used antibiotics with ileum terminal infusion to disrupt the hindgut microbiota, and investigated the changes in specific bacterial composition and immune indexes in the jejunum and colon, and serum of growing pigs. Twelve barrows (45 d of age, 12.08?±?0.28 kg) fitted with a T-cannula at the terminal ileum, were randomly assigned to two groups and infused either saline without antibiotics (Control) or with antibiotics (Antibiotic) at the terminal ileum. After 25 d experiment, all pigs were euthanized for analyzing bacterial composition and immune status.

Results

Ileum terminal antibiotic infusion (ITAI) altered dominant bacteria counts, with a decrease in Bifidobacterium, Clostridium cluster IV and Clostridium cluster IV in the colon (P?Escherichia coli in the jejunum (P?P?IL-10, Mucin-1 (MUC1), Mucin-2 (MUC2) and zonula occludens-1 (ZO-1) mRNA expression in the colonic mucosa (P?IFN-?, TNF-?, MUC2 and ZO-1 mRNA expression (P?P?ConclusionsITAI affected jejunal and colonic specific bacteria counts, and altered some immune markers levels in the jejunal and colonic mucosa and serum. These findings implicate the potential contribution of hindgut bacteria to immune response in the intestinal mucosa and serum of growing pigs.

SUBMITTER: Zhang C

PROVIDER: S-EPMC6027559 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Ileum terminal antibiotic infusion affects jejunal and colonic specific microbial population and immune status in growing pigs.

Zhang Chuanjian C Peng Yu Y Mu Chunlong C Zhu Weiyun W

Journal of animal science and biotechnology 20180702

<h4>Background</h4>Compared with oral antibiotics (primarily disrupt foregut microbiota), the present study used antibiotics with ileum terminal infusion to disrupt the hindgut microbiota, and investigated the changes in specific bacterial composition and immune indexes in the jejunum and colon, and serum of growing pigs. Twelve barrows (45 d of age, 12.08 ± 0.28 kg) fitted with a T-cannula at the terminal ileum, were randomly assigned to two groups and infused either saline without antibiotics ...[more]

PMID: 29988607

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Dataset Information

Ileum terminal antibiotic infusion affects jejunal and colonic specific microbial population and immune status in growing pigs.

Background

Results

Publications

Ileum terminal antibiotic infusion affects jejunal and colonic specific microbial population and immune status in growing pigs.

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