Ontology highlight
ABSTRACT:
SUBMITTER: Visweshwaran SP
PROVIDER: S-EPMC6028030 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Visweshwaran Sai P SP Thomason Peter A PA Guerois Raphael R Vacher Sophie S Denisov Evgeny V EV Tashireva Lubov A LA Lomakina Maria E ME Lazennec-Schurdevin Christine C Lakisic Goran G Lilla Sergio S Molinie Nicolas N Henriot Veronique V Mechulam Yves Y Alexandrova Antonina Y AY Cherdyntseva Nadezhda V NV Bièche Ivan I Schmitt Emmanuelle E Insall Robert H RH Gautreau Alexis A
The EMBO journal 20180529 13
The Arp2/3 complex generates branched actin networks that exert pushing forces onto different cellular membranes. WASH complexes activate Arp2/3 complexes at the surface of endosomes and thereby fission transport intermediates containing endocytosed receptors, such as α5β1 integrins. How WASH complexes are assembled in the cell is unknown. Here, we identify the small coiled-coil protein HSBP1 as a factor that specifically promotes the assembly of a ternary complex composed of CCDC53, WASH, and F ...[more]