Ontology highlight
ABSTRACT:
SUBMITTER: Imamura K
PROVIDER: S-EPMC6028032 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Imamura Katsutoshi K Takaya Akiko A Ishida Yo-Ichi YI Fukuoka Yayoi Y Taya Toshiki T Nakaki Ryo R Kakeda Miho M Imamachi Naoto N Sato Aiko A Yamada Toshimichi T Onoguchi-Mizutani Rena R Akizuki Gen G Tanu Tanzina T Tao Kazuyuki K Miyao Sotaro S Suzuki Yutaka Y Nagahama Masami M Yamamoto Tomoko T Jensen Torben Heick TH Akimitsu Nobuyoshi N
The EMBO journal 20180607 13
Cytoplasmic mRNA degradation controls gene expression to help eliminate pathogens during infection. However, it has remained unclear whether such regulation also extends to nuclear RNA decay. Here, we show that 145 unstable nuclear RNAs, including enhancer RNAs (eRNAs) and long noncoding RNAs (lncRNAs) such as NEAT1v2, are stabilized upon <i>Salmonella</i> infection in HeLa cells. In uninfected cells, the RNA exosome, aided by the Nuclear EXosome Targeting (NEXT) complex, degrades these labile t ...[more]