Genetic Modifiers in Neurodegeneration.
Ontology highlight
ABSTRACT:
SUBMITTER: Jain N
PROVIDER: S-EPMC6028053 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Genetic Modifiers in Neurodegeneration.
Jain Nimansha N Chen-Plotkin Alice S AS
Current genetic medicine reports 20180205 1
<h4>Purpose of review</h4>To review the evidence for genetic modifier effects in the neurodegenerative diseases Huntington's Disease (HD), Frontotemporal Lobar Degeneration (FTLD), Alzheimer's Disease (AD), and Parkinson's Disease (PD).<h4>Recent findings</h4>Increasingly, we understand human disease genetics less through the lens of single-locus/single-trait effects, and more through that of polygenic contributions to disease risk. In addition, specific examples of genetic modifier effects of t ...[more]
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