Ontology highlight
ABSTRACT:
SUBMITTER: Burns MB
PROVIDER: S-EPMC6028121 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Burns Michael B MB Montassier Emmanuel E Abrahante Juan J Priya Sambhawa S Niccum David E DE Khoruts Alexander A Starr Timothy K TK Knights Dan D Blekhman Ran R
PLoS genetics 20180620 6
Variation in the gut microbiome has been linked to colorectal cancer (CRC), as well as to host genetic variation. However, we do not know whether, in addition to baseline host genetics, somatic mutational profiles in CRC tumors interact with the surrounding tumor microbiome, and if so, whether these changes can be used to understand microbe-host interactions with potential functional biological relevance. Here, we characterized the association between CRC microbial communities and tumor mutation ...[more]