Ontology highlight
ABSTRACT:
SUBMITTER: Hartkamp R
PROVIDER: S-EPMC6028149 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Hartkamp Remco R Moore Timothy C TC Iacovella Christopher R CR Thompson Michael A MA Bulsara Pallav A PA Moore David J DJ McCabe Clare C
The journal of physical chemistry. B 20180320 12
The permeability of multicomponent phospholipid bilayers in the gel phase is investigated via molecular dynamics simulation. The physical role of the different molecules is probed by comparing multiple mixed-component bilayers containing distearylphosphatidylcholine (DSPC) with varying amounts of either the emollient isostearyl isostearate or long-chain alcohol (dodecanol, octadecanol, or tetracosanol) molecules. Permeability is found to depend on both the tail packing density and hydrogen bondi ...[more]