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Lipid-Protein Interactions Are Unique Fingerprints for Membrane Proteins.

ABSTRACT: Cell membranes contain hundreds of different proteins and lipids in an asymmetric arrangement. Our current understanding of the detailed organization of cell membranes remains rather elusive, because of the challenge to study fluctuating nanoscale assemblies of lipids and proteins with the required spatiotemporal resolution. Here, we use molecular dynamics simulations to characterize the lipid environment of 10 different membrane proteins. To provide a realistic lipid environment, the proteins are embedded in a model plasma membrane, where more than 60 lipid species are represented, asymmetrically distributed between the leaflets. The simulations detail how each protein modulates its local lipid environment in a unique way, through enrichment or depletion of specific lipid components, resulting in thickness and curvature gradients. Our results provide a molecular glimpse of the complexity of lipid-protein interactions, with potentially far-reaching implications for our understanding of the overall organization of real cell membranes.

SUBMITTER: Corradi V

PROVIDER: S-EPMC6028153 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Lipid-Protein Interactions Are Unique Fingerprints for Membrane Proteins.

Corradi Valentina V Mendez-Villuendas Eduardo E Ingólfsson Helgi I HI Gu Ruo-Xu RX Siuda Iwona I Melo Manuel N MN Moussatova Anastassiia A DeGagné Lucien J LJ Sejdiu Besian I BI Singh Gurpreet G Wassenaar Tsjerk A TA Delgado Magnero Karelia K Marrink Siewert J SJ Tieleman D Peter DP

ACS central science 20180613 6

Cell membranes contain hundreds of different proteins and lipids in an asymmetric arrangement. Our current understanding of the detailed organization of cell membranes remains rather elusive, because of the challenge to study fluctuating nanoscale assemblies of lipids and proteins with the required spatiotemporal resolution. Here, we use molecular dynamics simulations to characterize the lipid environment of 10 different membrane proteins. To provide a realistic lipid environment, the proteins a ...[more]

PMID: 29974066

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Dataset Information

Lipid-Protein Interactions Are Unique Fingerprints for Membrane Proteins.

Publications

Lipid-Protein Interactions Are Unique Fingerprints for Membrane Proteins.

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