Failure of ceftolozane-tazobactam salvage therapy in complicated pneumonia with lung abscess.
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ABSTRACT:
SUBMITTER: Lewis PO
PROVIDER: S-EPMC6028400 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Failure of ceftolozane-tazobactam salvage therapy in complicated pneumonia with lung abscess.
Lewis Paul O PO Cluck David B DB Tharp Jennifer L JL Krolikowski Matthew A MA Patel Paras D PD
Clinical case reports 20180528 7
Treatment of <i>Pseudomonas aeruginosa</i> remains challenging, despite the availability ceftolozane-tazobactam. We report a treatment failure with ceftolozane-tazobactam salvage therapy for pneumonia complicated by lung abscess. Drug resistance, dose selection, and source control are possible contributing factors. Ceftolozane-tazobactam susceptibility testing should precede therapy and consideration should be given to dosing selection. ...[more]
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