Ontology highlight
ABSTRACT:
SUBMITTER: Biedka S
PROVIDER: S-EPMC6028539 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Biedka Stephanie S Micic Jelena J Wilson Daniel D Brown Hailey H Diorio-Toth Luke L Woolford John L JL
The Journal of cell biology 20180424 7
Ribosome biogenesis involves numerous preribosomal RNA (pre-rRNA) processing events to remove internal and external transcribed spacer sequences, ultimately yielding three mature rRNAs. Removal of the internal transcribed spacer 2 spacer RNA is the final step in large subunit pre-rRNA processing and begins with endonucleolytic cleavage at the C<sub>2</sub> site of 27SB pre-rRNA. C<sub>2</sub> cleavage requires the hierarchical recruitment of 11 ribosomal proteins and 14 ribosome assembly factors ...[more]