Ontology highlight
ABSTRACT:
SUBMITTER: Dionne LK
PROVIDER: S-EPMC6028550 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Dionne Lai Kuan LK Shim Kyuhwan K Hoshi Masato M Cheng Tao T Wang Jinzhi J Marthiens Veronique V Knoten Amanda A Basto Renata R Jain Sanjay S Mahjoub Moe R MR
The Journal of cell biology 20180612 7
Centrosome number is tightly controlled to ensure proper ciliogenesis, mitotic spindle assembly, and cellular homeostasis. Centrosome amplification (the formation of excess centrosomes) has been noted in renal cells of patients and animal models of various types of cystic kidney disease. Whether this defect plays a causal role in cystogenesis remains unknown. Here, we investigate the consequences of centrosome amplification during kidney development, homeostasis, and after injury. Increasing cen ...[more]