Ontology highlight
ABSTRACT:
SUBMITTER: Morrison AH
PROVIDER: S-EPMC6028935 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Morrison Alexander H AH Byrne Katelyn T KT Vonderheide Robert H RH
Trends in cancer 20180430 6
Pancreatic cancer is the third-leading cause of cancer mortality in the USA, recently surpassing breast cancer. A key component of pancreatic cancer's lethality is its acquired immune privilege, which is driven by an immunosuppressive microenvironment, poor T cell infiltration, and a low mutational burden. Although immunotherapies such as checkpoint blockade or engineered T cells have yet to demonstrate efficacy, a growing body of evidence suggests that orthogonal combinations of these and other ...[more]