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Chemical Biology of H2S Signaling through Persulfidation.

ABSTRACT: Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H2S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.

SUBMITTER: Filipovic MR

PROVIDER: S-EPMC6029264 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Chemical Biology of H2S Signaling through Persulfidation.

Filipovic Milos R MR Zivanovic Jasmina J Alvarez Beatriz B Banerjee Ruma R

Chemical reviews 20171107 3

Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H2S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation. We cover ...[more]

PMID: 29112440

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