Kinetic models for activation and modulation of NMDA receptor subtypes.
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ABSTRACT:
SUBMITTER: Iacobucci GJ
PROVIDER: S-EPMC6029435 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Kinetic models for activation and modulation of NMDA receptor subtypes.
Iacobucci Gary J GJ Popescu Gabriela K GK
Current opinion in physiology 20180222
NMDA receptors are a diverse family of excitatory channels with critical roles in central synaptic transmission, development, and plasticity. Controlled expression of seven subunits and their combinatorial assembly into tetrameric receptors produces a range of molecularly distinct receptor subtypes. Despite relatively similar atomic structures, each subtype has input-output functions with unique biophysical and pharmacologic profiles. Here, we briefly summarize recent advances in understanding h ...[more]
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