Ontology highlight
ABSTRACT:
SUBMITTER: Lutz BM
PROVIDER: S-EPMC6029538 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Haematologica 20180315 7
Sickle cell disease is associated with acute painful episodes and chronic intractable pain. Endothelin-1, a known pain inducer, is elevated in the blood plasma of both sickle cell patients and mouse models of sickle cell disease. We show here that the levels of endothelin-1 and its endothelin type A receptor are increased in the dorsal root ganglia of a mouse model of sickle cell disease. Pharmacologic inhibition or neuron-specific knockdown of endothelin type A receptors in primary sensory neur ...[more]