Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura R
PROVIDER: S-EPMC6029773 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Nakamura Ryosuke R Ishii Hiroki H Endo Kaori K Hotta Asami A Fujii Eiji E Miyazawa Keiji K Saitoh Masao M
PloS one 20180703 7
Snail, also called Snai1, is a key regulator of EMT. Snail plays crucial roles in cancer progression, including resistance to anti-tumor drugs and invasion by various cancer cells. Slug, also known as Snai2, is also involved in the aggravation of certain tumors. In this study, we examined the roles of Slug in human oral squamous cell carcinoma (OSCC) cells. Slug is highly expressed in these cells, and Slug siRNA effectively represses anti-tumor drug resistance and invasive properties. In additio ...[more]