Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice.
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ABSTRACT:
SUBMITTER: Bhatti F
PROVIDER: S-EPMC6029784 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
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Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice.
Bhatti Faizah F Kung Johannes W JW Vieira Frederico F
PloS one 20180703 7
Surfactant proteins are important collectin immune molecules with a wide distribution throughout the body, including the ocular system. Mice with gene deletions for the surfactant protein genes Sftpa1 and Sftpd were observed to have visual impairment and thinning of the outer nuclear layers of the retina. We hypothesized that gene deletion of Sftpa1 and Sftpd (Sftpa1tm1Kor/J and Sftpd-/-) results in early retinal degeneration in these mice. Sftpa1tm1Kor/J and Sftpd-/- retinas were evaluated by h ...[more]
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