Sacituzumab Govitecan (IMMU-132) in treatment-resistant uterine serous carcinoma: A case report.

ABSTRACT: Background:Uterine serous carcinoma (USC) is a biologically aggressive variant of uterine cancer. Effective treatment options for recurrent, chemotherapy-resistant USC are extremely limited. Case:We describe a 74-year-old woman with recurrent and widespread treatment-resistant disease, who experienced a dramatic response to sacituzumab govitecan, a novel antibody-drug conjugate (ADC) targeting human trophoblast-cell-surface antigen (TROP-2), after failing multiple chemotherapy and immunotherapy. The impressive clinical response (66% reduction of target lesions by RECIST 1.1 with a duration response of over 10?months) was confirmed with serial CT scans in the absence of significant adverse events. Conclusion:Sacituzumab govitecan may present a new treatment option for recurrent USC patients harboring Trop-2+ tumors resistant to chemotherapy. Clinical trials with sacituzumab govitecan are warranted.

SUBMITTER: Han C 

PROVIDER: S-EPMC6030029 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature