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Elucidating the genetic basis of social interaction and isolation.


ABSTRACT: The negative impacts of social isolation and loneliness on health are well documented. However, little is known about their possible biological determinants. In up to 452,302 UK Biobank study participants, we perform genome-wide association study analyses for loneliness and regular participation in social activities. We identify 15 genomic loci (P?

SUBMITTER: Day FR 

PROVIDER: S-EPMC6030100 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Elucidating the genetic basis of social interaction and isolation.

Day Felix R FR   Ong Ken K KK   Perry John R B JRB  

Nature communications 20180703 1


The negative impacts of social isolation and loneliness on health are well documented. However, little is known about their possible biological determinants. In up to 452,302 UK Biobank study participants, we perform genome-wide association study analyses for loneliness and regular participation in social activities. We identify 15 genomic loci (P < 5 × 10<sup>-8</sup>) for loneliness, and demonstrate a likely causal association between adiposity and increased susceptibility to loneliness and de  ...[more]

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