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MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer.


ABSTRACT: The miR-133b, a commonly recognized muscle-specific miRNA, was reported to be deregulated in many kinds of cancers. However, its potential roles in tumorigenesis remain greatly elusive. Herein, we demonstrate that miR-133b is significantly suppressed in human breast cancer specimens, which is reversely correlated to histological grade of the cancer. Ectopic expression of miR-133b suppresses clonogenic ability and metastasis-relevant traits in vitro, as well as carcinogenesis and pulmonary metastasis in vivo. Further studies have identified Sox9, c-MET, and WAVE2 as direct targets of miR-133b, in which Sox9 contributes to all miR-133b-endowed effects including cell proliferation, colony formation, as well as cell migration and invasion in vitro. Moreover, re-expression of Sox9 reverses miR-133b-mediated metastasis suppression in vivo. Taken together, these findings highlight an important role for miR-133b in the regulation of tumorigenesis and metastatic potential of breast cancer and suggest a potential application of miR-133b in cancer treatment.

SUBMITTER: Wang QY 

PROVIDER: S-EPMC6030174 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer.

Wang Qiu-Yu QY   Zhou Ci-Xiang CX   Zhan Meng-Na MN   Tang Jun J   Wang Chen-Long CL   Ma Cheng-Ning CN   He Ming M   Chen Guo-Qiang GQ   He Jian-Rong JR   Zhao Qian Q  

Cell death & disease 20180703 7


The miR-133b, a commonly recognized muscle-specific miRNA, was reported to be deregulated in many kinds of cancers. However, its potential roles in tumorigenesis remain greatly elusive. Herein, we demonstrate that miR-133b is significantly suppressed in human breast cancer specimens, which is reversely correlated to histological grade of the cancer. Ectopic expression of miR-133b suppresses clonogenic ability and metastasis-relevant traits in vitro, as well as carcinogenesis and pulmonary metast  ...[more]

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