Ontology highlight
ABSTRACT:
SUBMITTER: Wang QY
PROVIDER: S-EPMC6030174 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Wang Qiu-Yu QY Zhou Ci-Xiang CX Zhan Meng-Na MN Tang Jun J Wang Chen-Long CL Ma Cheng-Ning CN He Ming M Chen Guo-Qiang GQ He Jian-Rong JR Zhao Qian Q
Cell death & disease 20180703 7
The miR-133b, a commonly recognized muscle-specific miRNA, was reported to be deregulated in many kinds of cancers. However, its potential roles in tumorigenesis remain greatly elusive. Herein, we demonstrate that miR-133b is significantly suppressed in human breast cancer specimens, which is reversely correlated to histological grade of the cancer. Ectopic expression of miR-133b suppresses clonogenic ability and metastasis-relevant traits in vitro, as well as carcinogenesis and pulmonary metast ...[more]