Ontology highlight
ABSTRACT:
SUBMITTER: van der Lubbe JEM
PROVIDER: S-EPMC6030213 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
van der Lubbe Joan E M JEM Huizingh Jeroen J Verspuij Johan W A JWA Tettero Lisanne L Schmit-Tillemans Sonja P R SPR Mooij Petra P Mortier Daniella D Koopman Gerrit G Bogers Willy M J M WMJM Dekking Liesbeth L Meijberg Wim W Kwaks Ted T Brandenburg Boerries B Tolboom Jeroen T B M JTBM Schuitemaker Hanneke H Roozendaal Ramon R Kuipers Harmjan H Zahn Roland C RC
NPJ vaccines 20180703
Seasonal vaccines are currently the most effective countermeasure against influenza. However, seasonal vaccines are only effective against strains closely related to the influenza strains contained in the vaccine. Recently a new hemagglutinin (HA) stem-based antigen, the so-called "mini-HA", has been shown to induce a cross-protective immune response in influenza-naive mice and non-human primates (NHP). However, prior exposure to influenza can have a profound effect on the immune response to sub ...[more]