Ontology highlight
ABSTRACT:
SUBMITTER: Park JE
PROVIDER: S-EPMC6030243 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Molecules and cells 20180612 6
Triglyceride homeostasis is a key process of normal development and is essential for the maintenance of energy metabolism. Dysregulation of this process leads to metabolic disorders such as obesity and hyperlipidemia. Here, we report a novel function of the <i>Drosophila</i> flightless-I <i>(fliI)</i> gene in lipid metabolism. <i>Drosophila fliI</i> mutants were resistant to starvation and showed increased levels of triglycerides in the fat body and intestine, whereas <i>fliI</i> overexpression ...[more]