The novel long noncoding RNA u50535 promotes colorectal cancer growth and metastasis by regulating CCL20.
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ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC6030363 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
The novel long noncoding RNA u50535 promotes colorectal cancer growth and metastasis by regulating CCL20.
Yu Xihu X Yuan Zixu Z Yang Zuli Z Chen Daici D Kim Taewan T Cui Yanmei Y Luo Qianxin Q Liu Zhihang Z Yang Zihuan Z Fan Xinjuan X Chen DianKe D Wang Lei L
Cell death & disease 20180703 7
Long noncoding RNAs (lncRNAs) have been emerging as master regulators of tumor growth and metastasis, but the functions and underlying mechanisms of lncRNAs in colorectal cancer (CRC) still need to be clarified. Here, we found a novel lncRNA u50535, which was greatly overexpressed in CRC tissues and was associated with poor prognosis in CRC patients. Function studies showed that u50535 was an oncogene in CRC both in vitro and in vivo. In mechanism, through RNA sequencing and rescue assay, we fou ...[more]
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