The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
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ABSTRACT:
SUBMITTER: Wall MJ
PROVIDER: S-EPMC6030446 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
Wall Mark J MJ Collins Dawn R DR Chery Samantha L SL Allen Zachary D ZD Pastuzyn Elissa D ED George Arlene J AJ Nikolova Viktoriya D VD Moy Sheryl S SS Philpot Benjamin D BD Shepherd Jason D JD Müller Jürgen J Ehlers Michael D MD Mabb Angela M AM Corrêa Sonia A L SAL
Neuron 20180531 6
Neuronal activity regulates the transcription and translation of the immediate-early gene Arc/Arg3.1, a key mediator of synaptic plasticity. Proteasome-dependent degradation of Arc tightly limits its temporal expression, yet the significance of this regulation remains unknown. We disrupted the temporal control of Arc degradation by creating an Arc knockin mouse (ArcKR) where the predominant Arc ubiquitination sites were mutated. ArcKR mice had intact spatial learning but showed specific deficits ...[more]
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