Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease.

ABSTRACT: When differential diagnosis of dementia includes both Alzheimer's disease (AD) and the behavioural variant of frontotemporal dementia (bvFTD), distribution of cerebral glucose metabolism as measured using [¹⁸F]‑2‑fluoro‑2‑deoxy‑d‑glucose positron emission tomography ([¹⁸F]FDG-PET) may be helpful. One important clue for differentiation is the presence of hypometabolism in the posterior cingulate cortex (PCC), usually associated with AD. PCC hypometabolism however, could also be present in bvFTD. Therefore, the specificity of PCC hypometabolism was examined. Based on visual reading PCC hypometabolism was present in 69-73/81 probable AD patients, in 10-16/33 probable bvFTD patients, and in 0-1/22 cognitive normal (CN) subjects. Findings were validated using a PCC to refe

SUBMITTER: Scheltens NME 

PROVIDER: S-EPMC6030576 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature