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Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells.


ABSTRACT: BACKGROUND:Apoptosis, the most well-known type of programmed cell death, can induce in a paracrine manner a proliferative response in neighboring surviving cells called apoptosis-induced proliferation (AiP). While having obvious benefits when triggered in developmental processes, AiP is a serious obstacle in cancer therapy, where apoptosis is frequently induced by chemotherapy. Therefore, in this study, we evaluated the capacity of an alternative type of cell death, called caspase-independent cell death, to promote proliferation. RESULTS:Using a novel in vitro isogenic cellular model to trigger either apoptosis or caspase-independent cell death, we found that the later has no obvious compensatory proliferation effects on neighboring cells. CONCLUSIONS:This study enforces the idea that alternative types of cell death such as caspase-independent cell death could be considered to replace apoptosis in the context of cancer treatment.

SUBMITTER: Roumane A 

PROVIDER: S-EPMC6030751 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells.

Roumane Ahlima A   Berthenet Kevin K   El Fassi Chaïmaa C   Ichim Gabriel G  

BMC cell biology 20180704 1


<h4>Background</h4>Apoptosis, the most well-known type of programmed cell death, can induce in a paracrine manner a proliferative response in neighboring surviving cells called apoptosis-induced proliferation (AiP). While having obvious benefits when triggered in developmental processes, AiP is a serious obstacle in cancer therapy, where apoptosis is frequently induced by chemotherapy. Therefore, in this study, we evaluated the capacity of an alternative type of cell death, called caspase-indepe  ...[more]

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