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Effects of low-molecular-weight chitosan on the growth performance, intestinal morphology, barrier function, cytokine expression and antioxidant system of weaned piglets.

ABSTRACT: BACKGROUND:Chitosan was used as an alternative to promote the growth of weaned piglets. And low-molecular-weight chitosan (LC) is one of chitosan derivatives and maintain beneficial biological properties of chitoson. The present experiment was carried out to examine the effects of LC on the growth performance, intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets. RESULTS:A total of 40 piglets weaned at 21 d of age, with average body weight 6.37?±?0.08 kg, were randomly assigned (5 pens/diet; 4 pigs/pen) to 2 treatments (a basal diet and the basal diet supplemented with 50 mg/kg LC) and were fed for 28 d. Compared with the control group, average daily feed intake (ADFI), and the expression of intestinal barrier protein ZO-1 was increased (P??0.05), gain-to-feed ratio (G:F, P?>?0.05), the incidence of diarrhea (P?>?0.05), or the antioxidant capacity (P?>?0.05) between two groups. The expression of IL-1? and TNF-? in jejunal mucosa were significantly decreased (P?

SUBMITTER: Hu S

PROVIDER: S-EPMC6030798 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Effects of low-molecular-weight chitosan on the growth performance, intestinal morphology, barrier function, cytokine expression and antioxidant system of weaned piglets.

Hu Shenglan S Wang Yu Y Wen Xiaolu X Wang Li L Jiang Zongyong Z Zheng Chuntian C

BMC veterinary research 20180704 1

<h4>Background</h4>Chitosan was used as an alternative to promote the growth of weaned piglets. And low-molecular-weight chitosan (LC) is one of chitosan derivatives and maintain beneficial biological properties of chitoson. The present experiment was carried out to examine the effects of LC on the growth performance, intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets.<h4>Results</h4>A total of 40 piglets weaned at 21 d of age, with average bod ...[more]

PMID: 29973213

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Dataset Information

Effects of low-molecular-weight chitosan on the growth performance, intestinal morphology, barrier function, cytokine expression and antioxidant system of weaned piglets.

Publications

Effects of low-molecular-weight chitosan on the growth performance, intestinal morphology, barrier function, cytokine expression and antioxidant system of weaned piglets.

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