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Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population.


ABSTRACT: Background:Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods:A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results:p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. Conclusion:The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

SUBMITTER: Akhter N 

PROVIDER: S-EPMC6030857 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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<h4>Background</h4>Genetic changes in p53 gene contribute to breast cancer susceptibility.<h4>Objective and methods</h4>A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women.<h4>Results</h4>p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer  ...[more]

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