Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population.
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ABSTRACT:
SUBMITTER: Akhter N
PROVIDER: S-EPMC6030857 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population.
Akhter Naseem N Dar Sajad A SA Chattopadhyay Shilpi S Haque Shafiul S Anwer Razique R Wahid Mohd M Jawed Arshad A Lohani Mohtashim M Mandal Raju K RK Shukla N K NK Abdul Yasir Y Husain Syed Akhtar SA
Current genomics 20180801 5
<h4>Background</h4>Genetic changes in p53 gene contribute to breast cancer susceptibility.<h4>Objective and methods</h4>A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women.<h4>Results</h4>p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer ...[more]
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