Infectivity of Chronic Malaria Infections and Its Consequences for Control and Elimination.
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ABSTRACT:
SUBMITTER: Aguas R
PROVIDER: S-EPMC6030896 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Infectivity of Chronic Malaria Infections and Its Consequences for Control and Elimination.
Aguas Ricardo R Maude Richard J RJ Gomes M Gabriela M MGM White Lisa J LJ White Nicholas J NJ Dondorp Arjen M AM
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20180701 2
Assessing the importance of targeting the chronic Plasmodium falciparum malaria reservoir is pivotal as the world moves toward malaria eradication. Through the lens of a mathematical model, we show how, for a given malaria prevalence, the relative infectivity of chronic individuals determines what intervention tools are predicted be the most effective. Crucially, in a large part of the parameter space where elimination is theoretically possible, it can be achieved solely through improved case ma ...[more]
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