Ontology highlight
ABSTRACT:
SUBMITTER: Yeo S
PROVIDER: S-EPMC6030987 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Yeo Sarah S Coombe Lauren L Warren René L RL Chu Justin J Birol Inanç I
Bioinformatics (Oxford, England) 20180301 5
<h4>Motivation</h4>Sequencing of human genomes is now routine, and assembly of shotgun reads is increasingly feasible. However, assemblies often fail to inform about chromosome-scale structure due to a lack of linkage information over long stretches of DNA-a shortcoming that is being addressed by new sequencing protocols, such as the GemCode and Chromium linked reads from 10 × Genomics.<h4>Results</h4>Here, we present ARCS, an application that utilizes the barcoding information contained in link ...[more]