Ontology highlight
ABSTRACT:
SUBMITTER: Rodrigues CH
PROVIDER: S-EPMC6031004 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Rodrigues Carlos Hm CH Ascher David B DB Pires Douglas Ev DE
Nucleic acids research 20180701 W1
Protein phosphorylation is tightly regulated due to its vital role in many cellular processes. While gain of function mutations leading to constitutive activation of protein kinases are known to be driver events of many cancers, the identification of these mutations has proven challenging. Here we present Kinact, a novel machine learning approach for predicting kinase activating missense mutations using information from sequence and structure. By adapting our graph-based signatures, Kinact repre ...[more]