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Identification and visualization of protein binding regions with the ArDock server.

ABSTRACT: ArDock (ardock.ibcp.fr) is a structural bioinformatics web server for the prediction and the visualization of potential interaction regions at protein surfaces. ArDock ranks the surface residues of a protein according to their tendency to form interfaces in a set of predefined docking experiments between the query protein and a set of arbitrary protein probes. The ArDock methodology is derived from large scale cross-docking studies where it was observed that randomly chosen proteins tend to dock in a non-random way at protein surfaces. The method predicts interaction site of the protein, or alternate interfaces in the case of proteins with multiple interaction modes. The server takes a protein structure as input and computes a score for each surface residue. Its output focuses on the interactive visualization of results and on interoperability with other services.

SUBMITTER: Reille S

PROVIDER: S-EPMC6031020 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Identification and visualization of protein binding regions with the ArDock server.

Reille Sébastien S Garnier Mélanie M Robert Xavier X Gouet Patrice P Martin Juliette J Launay Guillaume G

Nucleic acids research 20180701 W1

ArDock (ardock.ibcp.fr) is a structural bioinformatics web server for the prediction and the visualization of potential interaction regions at protein surfaces. ArDock ranks the surface residues of a protein according to their tendency to form interfaces in a set of predefined docking experiments between the query protein and a set of arbitrary protein probes. The ArDock methodology is derived from large scale cross-docking studies where it was observed that randomly chosen proteins tend to dock ...[more]

PMID: 29905873

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