Ontology highlight
ABSTRACT:
SUBMITTER: Brazill JM
PROVIDER: S-EPMC6031360 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Brazill Jennifer M JM Cruz Beverley B Zhu Yi Y Zhai R Grace RG Zhai R Grace RG
Disease models & mechanisms 20180612 6
Chemotherapy-induced peripheral neuropathy (CIPN) is the major dose-limiting side effect of many commonly used chemotherapeutic agents, including paclitaxel. Currently, there are no neuroprotective or effective symptomatic treatments for CIPN. Lack of understanding of the <i>in vivo</i> mechanisms of CIPN has greatly impeded the identification of therapeutic targets. Here, we optimized a model of paclitaxel-induced peripheral neuropathy using <i>Drosophila</i> larvae that recapitulates aspects o ...[more]