Ontology highlight
ABSTRACT:
SUBMITTER: Yu A
PROVIDER: S-EPMC6031449 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20180607 7
At central nervous system synapses, agonist binding to postsynaptic ionotropic glutamate receptors (iGluRs) results in signaling between neurons. N-Methyl-D-aspartic acid (NMDA) receptors are a unique family of iGluRs that activate in response to the concurrent binding of glutamate and glycine. Here, we investigate the process of agonist binding to the GluN2A (glutamate binding) and GluN1 (glycine binding) NMDA receptor subtypes using long-timescale unbiased molecular dynamics simulations. We fi ...[more]