Mito-TEMPO improves development competence by reducing superoxide in preimplantation porcine embryos.
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ABSTRACT:
SUBMITTER: Yang SG
PROVIDER: S-EPMC6031607 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Mito-TEMPO improves development competence by reducing superoxide in preimplantation porcine embryos.
Yang Seul-Gi SG Park Hyo-Jin HJ Kim Jin-Woo JW Jung Jae-Min JM Kim Min-Ji MJ Jegal Ho-Guen HG Kim In-Su IS Kang Man-Jong MJ Wee Gabbine G Yang Hee-Young HY Lee Yun-Han YH Seo Ji-Hae JH Kim Sun-Uk SU Koo Deog-Bon DB
Scientific reports 20180704 1
Mito-TEMPO is a well-known mitochondria-specific superoxide scavenger. However, the effect of Mito-TEMPO on porcine embryo development, to our knowledge, has not been studied yet. In the present study, porcine embryos were classified into two groups (G1 and G2) based on the cytoplasm lipid contents at the zygote stage. The development of blastocysts derived from G2 zygotes was reduced (G2:16.2 ± 7.9% vs G1: 26.5 ± 5.9%; 1.6-fold, p < 0.05) compared to those from G1 zygotes. In G2 embryos, the pr ...[more]
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