Role of neuritin in retinal ganglion cell death in adult mice following optic nerve injury.
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ABSTRACT:
SUBMITTER: Azuchi Y
PROVIDER: S-EPMC6031618 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Role of neuritin in retinal ganglion cell death in adult mice following optic nerve injury.
Azuchi Yuriko Y Namekata Kazuhiko K Shimada Tadayuki T Guo Xiaoli X Kimura Atsuko A Harada Chikako C Saito Atsuko A Yamagata Kanato K Harada Takayuki T
Scientific reports 20180704 1
Neuritin is a small extracellular protein that plays important roles in the process of neural development, synaptic plasticity, and neural cell survival. Here we investigated the function of neuritin in a mouse model of optic nerve injury (ONI). ONI induced upregulation of neuritin mRNA in the retina of WT mice. The retinal structure and the number of retinal ganglion cells (RGCs) were normal in adult neuritin knockout (KO) mice. In vivo retinal imaging and histopathological analyses demonstrate ...[more]
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