Ontology highlight
ABSTRACT:
SUBMITTER: Park S
PROVIDER: S-EPMC6031629 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Park Solip S Supek Fran F Lehner Ben B
Nature communications 20180704 1
The genetic causes of cancer include both somatic mutations and inherited germline variants. Large-scale tumor sequencing has revolutionized the identification of somatic driver alterations but has had limited impact on the identification of cancer predisposition genes (CPGs). Here we present a statistical method, ALFRED, that tests Knudson's two-hit hypothesis to systematically identify CPGs from cancer genome data. Applied to ~10,000 tumor exomes the approach identifies known and putative CPGs ...[more]