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Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis.

ABSTRACT: It is unknown how much different are the clinical outcomes between asymptomatic and symptomatic patients with severe aortic stenosis (AS). In the CURRENT AS registry enrolling 3,815 consecutive patients with severe AS, we compared the long-term outcomes between 1808 asymptomatic and 1215 symptomatic patients (exertional dyspnea: N?=?813, syncope: N?=?136, and angina: N?=?266) without heart failure (HF) hospitalization. Symptomatic patients had greater AS severity, and more depressed left ventricular function than asymptomatic patients without much difference in other baseline characteristics. During a median follow-up of 3.2 years, aortic valve replacement (AVR) was performed in 62% of symptomatic patients, and 38% of asymptomatic patients. The cumulative 5-year incidences for the primary outcome measure (a composite of aortic valve-related death or HF hospitalization) was higher in symptomatic patients than in asymptomatic patients (32.3% versus 27.6%, P?

SUBMITTER: Kanamori N 

PROVIDER: S-EPMC6031663 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis.

Kanamori Norio N   Taniguchi Tomohiko T   Morimoto Takeshi T   Shiomi Hiroki H   Ando Kenji K   Murata Koichiro K   Kitai Takeshi T   Kawase Yuichi Y   Izumi Chisato C   Miyake Makoto M   Mitsuoka Hirokazu H   Kato Masashi M   Hirano Yutaka Y   Matsuda Shintaro S   Nagao Kazuya K   Inada Tsukasa T   Mabuchi Hiroshi H   Takeuchi Yasuyo Y   Yamane Keiichiro K   Toyofuku Mamoru M   Ishii Mitsuru M   Minamino-Muta Eri E   Kato Takao T   Inoko Moriaki M   Ikeda Tomoyuki T   Komasa Akihiro A   Ishii Katsuhisa K   Hotta Kozo K   Higashitani Nobuya N   Kato Yoshihiro Y   Inuzuka Yasutaka Y   Maeda Chiyo C   Jinnai Toshikazu T   Morikami Yuko Y   Saito Naritatsu N   Minatoya Kenji K   Aoyama Takeshi T   Kimura Takeshi T  

Scientific reports 20180704 1

It is unknown how much different are the clinical outcomes between asymptomatic and symptomatic patients with severe aortic stenosis (AS). In the CURRENT AS registry enrolling 3,815 consecutive patients with severe AS, we compared the long-term outcomes between 1808 asymptomatic and 1215 symptomatic patients (exertional dyspnea: N = 813, syncope: N = 136, and angina: N = 266) without heart failure (HF) hospitalization. Symptomatic patients had greater AS severity, and more depressed left ventric  ...[more]

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